Approximately one in 20 people report using cannabis while pregnant, making it the most used federally illicit substance by pregnant people in the U.S., according to SAMSHA. The potential harms of perinatal cannabis use to maternal, fetal, and newborn health are well-documented. This publication is intended as a resource for state MCH professionals in designing and implementing public health approaches that prevent and mitigate the harm of perinatal cannabis use to pregnant and postpartum people and their families.